New article published in ACS infectious diseases!

Part of the research performed in the group during the last years pursuing the development of novel diagnostic techniques for bacterial infectious diseases has resulted in a new accepted paper: Direct Quantitative Immunochemical Analysis of the Autoinducer Peptide IV (AIP-IV) for Diagnosing and Stratifying Staphylococcus aureus infections.

This work has been performed in collaboration with the group of Dr. Miriam Royo (IQAC-CSIC) and the Microbiology Service of the Hospital Germans Trias i Pujol (Alicia Lacoma and Cristina Prat), and reports an immunoassay with excellent analytical features, aiming at the detection and quantification of the autoinducer peptide IV, a relevant molecule of the Quorum Sensing system of Staphylococcus aureus bacteria. A pilot study with a set of clinical isolates from patients with airways infection or colonization demonstrates the potential of this assay to perform biomedical investigations related to the role of QS in pathogenesis and the association between dysfunctional agr or the agr type with unfavorable clinical outcomes. Besides, it appears as a potential technology for phenotyping S. aureus.

This very nice work arises from the Nb4D QS4CF, IMMUNO-QS (funded by the Spanish Government) and QS-MOTION (by La Marató de TV3 Foundation) projects.

ACS Infect. Dis., 8(3), 645-656, 2022. DOI: 10.1021/acsinfecdis.1c00670).